Written by Eric Potratz

In this article we will follow the palm fruit phytonutrients through the human body.

This article will focus on the fat soluble phytonutrients: tocotrienols and carotenoids. We will move through digestion, circulation, and biological tissues. You will see where and when these phytonutrients appear in the body and a few of their unique actions.

 

After 1 hour : Digesting & Absorbing

The phytonutrients in Palm Fruit are fat soluble, so they require fat to be properly absorbed. (1) For ideal absorption at least 5 g of fat should be consumed with the capsules. This will trigger the digestive tract to release bile, which helps dissolve the phytonutrients for optimal absorption. (1,2)

Within 1-2 hours the phytonutrients will begin passing through the intestinal walls, where they will begin absorbing into the circulatory system(s). (3-5)

After 6 hours : Circulating in the Blood

Once the fat soluble phytonutrients pass through the intestinal tissue, they take two routes of transportation (6) –

1. Lymphatic circulation: This pathway allows the phytonutrients to bypass the liver, and diffuse directly into the bloodstream.
2. Portal venous circulation: This pathway takes the antioxidants directly to the liver. Once in the liver, the antioxidants are either stored, excreted, or released into blood circulation.

Once in circulation, the phytonutrients get packed into fat or cholesterol particles (e.g., chylomicrons, LDL, HDL, etc.) which act as vehicles for transporting the phytonutrients throughout the body. (6) Regardless of the pathway, the phytonutrients travel through circulation for 6-12 hours before they reach their ultimate destination; our living cells.

 

After 1 day : Reaching Target Organs

Within 24 hours the phytonutrients reach all major organs in the body, (5) but it takes several weeks for the concentration to build up high enough to start producing a positive effect.

Lets skip ahead a few weeks and get to the exciting stuff.

Phytonutrients incorporate into the newly formed skin cells in the dermis which replace older skin cells as the new cells push upwards.

 

After 4 weeks : Penetrating Cell Tissue

All organs in the body absorb fat soluble phytonutrients to some extent, but tocotrienol and carotenoid molecules are attracted to circulatory and skin tissue more than other tissues because of their specific biological composition. (7-9) The antioxidant protection against free radical damage is one of the first benefits to be achieved from Palm Fruit supplementation –

Circulatory tissue: In blood vessels, the phytonutrients are absorbed into the endothelial tissue. (10) In this inner vessel tissue, which also holds embedded cholesterol particles, the phytonutrients immediately relieve several points of free radical stress in the vessel wall –

• Reduces cholesterol mutation; reducing plaque formation (11-12)
• Extends activity of nitric oxide; improving dilation of vessels (13)
• Reduces AGEs; improving dilation of vessels (14)

Skin tissue: The blood capillaries deliver phytonutrients to the dermis; where new skin cells are generated and enriched with phytonutrients. After 6-8 weeks, the newly enriched skin cells will have replaced the older skin cells throughout the dermis and epidermis, leading to several improvements –

• Imparts carotenoid coloration; improving skin pigmentation (15)
• Protects the cellular membrane; increasing skin hydration (16)
• Reduces sun (UV) damage; preventing collagen breakdown (17)

Hair follicles: Blood capillaries feed the phytonutrients directly into the root of the hair follicle which contains the fastest generating cells in the human body, and thus a significant amount of free radicals. (18) The phytonutrients immediately begin clearing out this abundance of free radicals, which has the following effects –

• Eliminates free radical interference; prolonging the growth phase (18)
• Prevents fat & protein oxidation; improving nutrient assimilation (19)
• Protects melanocytes; preventing greying of hair (19)

 

After 12 weeks : Activating Cell Functions

After 12 weeks, the phytonutrients reach a sufficient concentration within the cells to begin influencing cell behavior. (20-22) Optimizing cell behavior extends beyond the antioxidant action and involves direct action upon cell receptors; triggering the production of various enzymes, peptides, and hormones. Here are some of the effects –

Circulatory tissue:

• Increases APOA-1; removing plaque from arteries (20)
• Increases CRP; supporting optimal blood flow (20)
• Reduces VCAM-1; preventing artery plaque formation (21)

Skin tissue:

• Increases collagen synthesis; improving skin firmness (22)
• Optimizes PPAR; improving skin moisturization (23,24)
• Lowers MMP; preserving skin elasticity (17)

Hair follicles:

• Reduces IL-1b; reducing hair loss (21,25)
• Increases PPARy; protecting hair follicle (23,26)
• Reduces TGF-B1; preventing hair follicle death (14,27)

 

After 6 months : Reversing DNA Damage

DNA contains the instructions for the structure and function of our cells. The integrity of our DNA directly impacts our health and appearance. (28-30) Aging is a result of slowly accumulated DNA damage, and individuals who appear older, have a higher degree of DNA damage. (32) Therefore, preventing or reversing DNA damage can minimize or reverse signs of aging.

After 3-6 months, tocotrienols and carotenoids reach a critical concentration around the DNA –

• Reduces strand breaks; reducing DNA damage (30,31)
• Rejoins DNA strand breaks; repairing DNA (28,29)
• Increases PARP; enhancing DNA repair (28)

 

After 12 months : Keeping the Body Protected

After 12 months, the palm fruit tocotrienols and carotenoids reach their optimal concentration throughout all organs in the body. (8)

Continuing to dose Palm Fruit will ensure the repair and & regenerative benefits are maintained, while continuing to slow the aging process in the future. (30)

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If you haven’t already, be sure to get started on our Palm Fruit Subscription Plan. It’s a great way to ensure you have a consistent supply shipped to your door each month. Shipping is always free and you will pay a discounted price of only $39.99 per month.

I hope you enjoy the journey.

References

1.Relationships between the molecular structures and emulsification properties of edible oils.
Masami et al.
Biosci. Biotech. Biochem 58 (7), 1258-1261, 1994

2. Effects of fats and oils on the bioaccessibility of carotenoids and vitamin e in vegetables.
Nagao A, et al.
Biosci Biotechnol Biochem. 2013 May 23;77(5):1055-60.

3. Influence of lipolysis and droplet size on tocotrienol absorption from self-emulsifying formulations.
Yap SP, et al.
Int J Pharm. 2004 Aug 20;281(1-2):67-78.

4. Comparative Bioavailability Study Of Powder and Oily Formulation in Rats
Prof. Yuen, et al.
Hovid Bhd. (2011)

5. Postprandial metabolic fate of tocotrienol-rich vitamin E differs significantly from that of alpha-tocopherol.
Fairus S, et al.
Am J Clin Nutr. 2006 Oct;84(4):835-42.

6. Delivery of orally supplemented alpha-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice.
Khanna S, et al.
Free Radic Biol Med. 2005 Nov 15;39(10):1310-9.

7. Diet-derived and topically applied tocotrienols accumulative in skin and protect the tissue against ultraviolet light-induced oxidative stress.  
Traber M G, et al.
Asia Pacific journal of Clinical Nutrition 6(1): 63–67. (1997)

8. Natural vitamin E alpha-tocotrienol: retention in vital organs in response to long-term oral supplementation and withdrawal.
Patel V, et al.
Free Radic Res. 2006 Jul;40(7):763-71.

9. Oral tocotrienols are transported to human tissues and delay the progression of the model for end-stage liver disease score in patients.
Patel V, et al.
J Nutr. 2012 Mar;142(3):513-9.

10. Characterization of cellular uptake and distribution of vitamin E.
Saito Y, et al.
Ann N Y Acad Sci. 2004 Dec;1031:368-75.

11. Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study.
Chin SF, et al.
Nutr Metab (Lond). 2011 Jun 24;8(1):42.

12. Studies of LDL oxidation following alpha-, gamma-, or delta-tocotrienyl acetate supplementation of hypercholesterolemic humans.
O’Byrne D., et al.
Free Radic Biol Med. 2000 Nov 1;29(9):834-45.

13. Arterial compliance and vitamin E blood levels with a self emulsifying preparation of tocotrienol rich vitamin E.
Rasool AH, et al.
Arch Pharm Res. 2008 Sep;31(9):1212-7.

14.  AGEs (advanced glycation end products)
Tocotrienols reverse cardiovascular, metabolic and liver changes in high carbohydrate, high fat diet-fed rats.
Wong WY, et al.
Nutrients. 2012 Oct 22;4(10):1527-41.

15. Attractive skin coloration: harnessing sexual selection to improve diet and health.
Whitehead RD, et al.
Evol Psychol. 2012 Dec 20;10(5):842-54.

16. Cosmetic benefit of dietary supplements including astaxanthin and tocotrienol on human skin.
Yamashita E, et al.
Food Style 21 6: 112–117. (2002)

17. The role of antioxidants in photoprotection: a critical review.
Chen L, et al.
J Am Acad Dermatol. 2012 Nov;67(5):1013-24.

18. Low dose oxidative stress induces mitochondrial damage in hair cells.
Baker K. et al
Anat Rec (Hoboken). 2012 Nov;295(11):1868-76.

19. Oxidative stress in ageing of hair.
Trüeb RM.
Int J Trichology. 2009 Jan;1(1):6-14.

20. Supplementation with tocotrienol-rich fraction alters the plasma levels of Apolipoprotein A-I precursor, Apolipoprotein E precursor, and C-reactive protein precursor from young and old individuals.
Heng EC, et al.
Eur J Nutr. 2013 Jan 4.

21. Tocotrienols and its role in cardiovascular health–a lead for drug design.
Vasanthi HR, et al.
Curr Pharm Des. 2011;17(21):2170-5. Review.

22. Modulation of collagen synthesis and its gene expression in human skin fibroblasts by tocotrienol-rich fraction.
Makpol S., et al.
Arch Med Sci. 2011 Oct;7(5):889-95.

23. Vitamin E tocotrienols improve insulin sensitivity through activating peroxisome proliferator-activated receptors.
Fang F, et al.
Mol Nutr Food Res. 2010 Mar;54(3):345-52.

24. Peroxisome proliferator-activated receptors (PPARs) in skin health, repair and disease.
Michalik L, Wahli W (2007)
Biochim Biophys Acta 1771: 991–998.

25. Contribution of interleukin 1beta and KM loci to alopecia areata.
Galbraith GM., et al.
Hum Hered. 1999 Mar;49(2):85-9.

26. Scarring alopecia and the PPAR-gamma connection.
Harries MJ., et al.
J Invest Dermatol. 2009 May;129(5):1066-70.

27. Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells.
Shin H., et al.
BMB Rep. 2013 Sep;46(9):460-4.

28. Tocotrienols promote apoptosis in human breast cancer cells by inducing poly(ADP-ribose) polymerase cleavage and inhibiting nuclear factor kappa-B activity.
Loganathan R, et al.
Cell Prolif. 2013 Apr;46(2):203-13.

29. Effects of micronutrients on DNA repair.
Collins AR, et al.
Eur J Nutr. 2012 Apr;51(3):261-79.

30. Reduction of DNA damage in older healthy adults by Tri E Tocotrienol supplementation.
Chin SF., et al.
Nutrition. 2008 Jan;24(1):1-10.

31. Tocotrienol rich fraction (TRF) supplementation protects against oxidative DNA damage and improves cognitive functions in Wistar rats.
Taridi NM, et al.
Clin Ter. 2011;162(2):93-8.

32. Aging is associated with quantitative and qualitative changes in circulating cell-free DNA: the Vitality 90+ study.
Jylhävä J., et al.
Mech Ageing Dev. 2011 Jan-Feb;132(1-2):20-6.

 

original article 

https://blog.botanicalcraft.com/absorption-of-palm-fruit-the-12-month-biological-journey/#more-75