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Toco-9

Plant-based nutrients proven to slow and reverse the aging process 

Supported by more human clinical research than any other anti‑aging supplement in the world.

Toco-9 phytonutrient supplement

60 vegetarian liquidcapsules | 30 day supply
  • Support the skins UV defense
  • Regenerate youthful skin
  • Reverse age-related hair loss

 

 

† These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.


Scientifically validated active ingredients
Clinically effective dose of tocochromanols, carotenoids, and sesamin

 

Red palm oil extract | 20% palm phytonutrients
Contains dozens of naturally occurring fat-soluble tocotrienols, tocopherols, and carotenoids. (1, 2) Toco-9 provides 160 mg of tocochromanols and 30 mg of carotenoids, which is supported by 35+ human clinical trials for their safety and effectiveness. (3–38).

 

Sesame seed extract | 90% sesamin
Contains a fat-soluble lignan known as sesamin, which increases the body's retention of the vitamin E family, including tocotrienols and tocopherols. (39, 40) Each serving provides 90 mg of sesamin which is clinically effective for enhancing the benefits from palm-based phytonutrients. (41–43).

 

.
Hypromellose capsule | water‑sealed
Made from 100% plant-based cellulose material. The capsule is hermetically sealed to help protect the oxygen sensitive ingredients. Our liquid encapsulation technology avoids all chemical preservatives, fillers, and binders.

 

Supports the skin’s UV defense
Supports the skin's natural defense against UVA and UVB to minimize redness and photoaging from mild sun exposure. (1–3)

 

  • Shown to increase the skin's tolerance to sunlight by up to 240% after 12 weeks of supplementation in healthy adults. (1-4)
  • Carotenoids, tocochromanols, and sesamin help dissipate UV radiation from the sun by supporting the skin’s natural antioxidant functions. (8-10) This helps protect the skin’s DNA, cellular membranes, and collagen from mild sun exposure. (1, 4–7)
  • It is recommended to supplement with Toco-9 daily for at least 12 weeks for the greatest sun protective benefits. (9) Toco-9 is not intended to replace sunscreen or other effective sun protective measures.
  •  

    Regenerates youthful skin
    Enhances skin softness and hydration, and prevents age-related DNA damage. (1–4, ‡)

     

  • Shown to significantly reduce the appearance of wrinkles after 4 weeks in healthy middle-aged women. (1, )
  • Improves skin health by restoring cellular hydration, stimulating synthesis of type-1 collagen, and reducing DNA damage associated with aging. (2–6)
  • For the best results, it is recommended to supplement with Toco-9 daily for at least 12 weeks to achieve full saturation of tocochromanols and carotenoids throughout the dermis and epidermis. (7–9)
  •  

    Reverses age-related hair loss
    Increases the number of hairs on the scalp, without side-effects. (1, 2)

     

  • Shown to increase the number of hairs on the scalp by an average of 38% after 8 months in men and women suffering from age-related hair loss. (1, 2)
  • Triggers hair growth by stimulating insulin like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), and keratinocyte growth factor (KGF) in aging hair follicles. (3–6)
  • Toco-9 can be used safely with minoxidil (Rogaine®) and/or finasteride (Propecia®). It is recommended by cosmetic surgeons to supplement with the palm-based extract in Toco-9 before and after hair transplantation surgery for the most successful hair regrowth. (7)
  •  

    References

    • References

      Toco-9 Ingredients

      Iconic Formulations ensures all ingredients meet FDA GMP requirements and are verified to be free of harmful pesticides, solvents, heavy metals, aflatoxins, and other contaminates.

      1. Ping BTY, May CY. 2000. Practical guide to establishing palm carotenoids profiles by HPLC with three dimensional diode array detector. Palm Oil Developments, pp. 13–17
      2. Han NM, May CY. 2012. Chromatographic analyses of tocopherols and tocotrienols in palm oil. J. Chromatogr. Sci. 50(3):283–86
      3. Keong CC, Singh HJ, Singh R. 2006. Effects of palm vitamin E supplementation on exercise-induced oxidative stress and endurance performance in the heat.J. Sports Sci. Med. 5(4):629–39
      4. Meinke MC, Friedrich A, Tscherch K, et al. 2012. Influence of dietary carotenoids on radical scavenging capacity of the skin and skin lipids. Eur. J. Pharm. Biopharm. 84(2):365–73
      5. Césarini JP, Michel L, Maurette JM, et al. 2003. Immediate effects of UV radiation on the skin: modification by an antioxidant complex containing carotenoids. Photodermatol. Photoimmunol. Photomed. 19(4):182–89
      6. Heinrich U, Gärtner C, Wiebusch M, et al. 2003. Supplementation with beta-carotene or a similar amount of mixed carotenoids protects humans from UV-induced erythema. J. Nutr. 133(1):98–101
      7. Yamashita E. 2002. Cosmetic benefit of dietary supplements including astaxanthin and tocotrienol on skin. FOOD Style. 21(6(6)):112–17
      8. Stahl W, Heinrich U, Jungmann H, et al. 2000. Carotenoids and carotenoids plus vitamin E protect against ultraviolet light–induced erythema in humans.Am. J. Clin. Nutr. 71(3):795–98
      9. Lee J, Jiang S, Levine N, et al. 2000. Carotenoid supplementation reduces erythema in human skin after simulated solar radiation exposure. Proc. Soc. Exp. Biol. Med. 223(2):170–74
      10. Gollnick HPM, Hopfenmüller W, Hemmes C, et al. 1996. Systemic beta carotene plus topical UV-sunscreen are an optimal protection against harmful effects of natural UV-sunlight: results of the berlin-eilath study. European journal of dermatology. 6(3)(200-205)
      11. Beoy LA, Woei WJ, Hay* YK. 2010. Effects of tocotrienol supplementation on hair growth in humans. Tropical Life Sciences Research. 21(2):91–99
      12. Ho DSS, Yuen KH, Wong JW, et al. 2007. Palm fruit extract for hair growth: a human clinical trial. US Patent 7211274 B2
      13. Gopalan Y, Shuaib IL, Magosso E, et al. 2014. Clinical investigation of the protective effects of palm vitamin e tocotrienols on brain white matter. Stroke. 45(5):1422–28
      14. Magosso E, Ansari MA, Gopalan Y, et al. 2013. Tocotrienols for normalisation of hepatic echogenic response in nonalcoholic fatty liver: a randomised placebo-controlled clinical trial. Nutr. J. 12(1):166
      15. Arguillas M. 2013. The effect of vitamin E (mixed tocotrienol) on the liver stiffness measurement measured by transient elastography (fibroscan) among nafld patients. APAS Liver Week. Singapore
      16. Patel V, Rink C, Gordillo GM, et al. 2012. Oral tocotrienols are transported to human tissues and delay the progression of the model for end-stage liver disease score in patients. J. Nutr. 142(3):513–19
      17. Magosso E. 2010. Tocotrienols and nonalcoholic fatty liver: a clinical experience
      18. Mahalingam D, Radhakrishnan AK, Amom Z, et al. 2010. Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers. Eur. J. Clin. Nutr. 65(1):63–69
      19. Chin S-F, Hamid NAA, Latiff AA, et al. 2007. Reduction of DNA damage in older healthy adults by Tri E tocotrienol supplementation. Nutrition. 24(1):1–10
      20. Astley SB, Elliott RM, Archer DB, et al. 2004. Evidence that dietary supplementation with carotenoids and carotenoid-rich foods modulates the DNA damage: repair balance in human lymphocytes. Br. J. Nutr. 91(1):63–72
      21. Torbergsen AC, Collins AR. 2000. Recovery of human lymphocytes from oxidative DNA damage; the apparent enhancement of dna repair by carotenoids is probably simply an antioxidant effect. Eur. J. Nutr. 39(2):80–85
      22. Heng KS, Hejar AR, Johnson Stanslas J, et al. 2015. Potential of mixed tocotrienol supplementation to reduce cholesterol and cytokines level in adults with metabolic syndrome. Malaysian Journal of Nutrition. 21(2):231–43
      23. Heng EC, Karsani SA, Abdul Rahman M, et al. 2013. Supplementation with tocotrienol-rich fraction alters the plasma levels of apolipoprotein a-i precursor, apolipoprotein e precursor, and c-reactive protein precursor from young and old individuals. Eur. J. Nutr. 52(7):1811–20
      24. Chin S-F, Ibahim J, Makpol S, et al. 2011. Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: a randomized controlled study. Nutr. Metab. 8(1):42
      25. Yuen K, Wong J, Lim A. 2011. Effect of mixed-tocotrienols in hypercholesterolemic subjects. Functional Foods in Health and Disease: 3:106-117
      26. Rasool AHG, Rahman ARA, Yuen KH, et al. 2008. Arterial compliance and vitamin E blood levels with a self emulsifying preparation of tocotrienol rich vitamin E. Arch. Pharm. Res. 31(9):1212–17
      27. Ajuluchukwu JNA, Okubadejo NU, Mabayoje M, et al. 2007. Comparative study of the effect of tocotrienols and -tocopherol on fasting serum lipid profiles in patients with mild hypercholesterolaemia: a preliminary report. Niger. Postgrad. Med. J. 14(1):30–33
      28. Rasool AHG, Yuen KH, Yusoff K, et al. 2006. Dose dependent elevation of plasma tocotrienol levels and its effect on arterial compliance, plasma total antioxidant status, and lipid profile in healthy humans supplemented with tocotrienol rich vitamin E. J. Nutr. Sci. Vitaminol. 52(6):473–78
      29. Baliarsingh S, Beg ZH, Ahmad J. 2005. The therapeutic impacts of tocotrienols in type 2 diabetic patients with hyperlipidemia. Atherosclerosis. 182(2):367–74
      30. Mustad VA, Smith CA, Ruey PP, et al. 2002. Supplementation with 3 compositionally different tocotrienol supplements does not improve cardiovascular disease risk factors in men and women with hypercholesterolemia. Am. J. Clin. Nutr. 76(6):1237–43
      31. Mensink RP, van Houwelingen AC, Kromhout D, et al. 1999. A vitamin E concentrate rich in tocotrienols had no effect on serum lipids, lipoproteins, or platelet function in men with mildly elevated serum lipid concentrations. Am. J. Clin. Nutr. 69(2):213–19
      32. Tomeo AC, Geller M, Watkins TR, et al. 1995. Antioxidant effects of tocotrienols in patients with hyperlipidemia and carotid stenosis. Lipids. 30(12):1179–83
      33. Qureshi AA, Bradlow BA, Brace L, et al. 1995. Response of hypercholesterolemic subjects to administration of tocotrienols. Lipids. 30(12):1171–77
      34. Wahlqvist ML, Krivokuca-Bogetic Z, Lo CS, et al. 1992. Differential serum responses of tocopherols and tocotrienols during vitamin supplementation in hypercholesterolaemic individuals without change in coronary risk factors.NUTRITION RESEARCH. 12(Suppl. 1):S181-S201
      35. Atroshi F, Antila E, Sankari S, et al. 1992. Palm oil vitamin e effects in hypercholesterolemia. In Lipid-Soluble Antioxidants: Biochemistry and Clinical Applications, pp. 575–81. Birkhäuser Basel
      36. Teoh M, Chong M, Jamaludin M. Effects of tocotrienol-rich vitamin E on patients with peripheral vascular disease. In Lipid-Soluble Antioxidants: Biochemistry and Clinical Applications, ed A Ong, L Packer, pp. 606–21. Birkhäuser Basel
      37. Tan DT, Khor HT, Low WH, et al. 1991. Effect of a palm-oil-vitamin e concentrate on the serum and lipoprotein lipids in humans. Am. J. Clin. Nutr. 53(4 Suppl):1027S – 1030S
      38. Qureshi AA, Qureshi N, Wright JJ, et al. 1991. Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (Palmvitee). Am. J. Clin. Nutr. 53(4 Suppl):1021S – 1026S
      39. Frank J, Lee S, Leonard SW, et al. 2008. Sex diffs in the inhibition of gamma-tocopherol metabolism by a single dose of dietary sesame oil in healthy subjects. Am. J. Clin. Nutr. 87(6):1723–29
      40. Cooney RV, Custer LJ, Okinaka L, et al. 2001. Effects of dietary sesame seeds on plasma tocopherol levels. Nutr. Cancer. 39(1):66–71
      41. Yamada Y, Obayashi M, Ishikawa T, et al. 2008. Dietary tocotrienol reduces UVB-induced skin damage and sesamin enhances tocotrienol effects in hairless mice. J. Nutr. Sci. Vitaminol. 54(2):117–23
      42. Takemoto D, Yasutake Y, Tomimori N, et al. 2015. Sesame lignans and vitamin E supplementation improve subjective statuses and anti-oxidative capacity in healthy humans with feelings of daily fatigue. Glob. J. Health Sci. 7(6):1–10
      43. Yamashita K, Iizuka Y, Imai T, et al. 1995. Sesame seed and its lignans produce marked enhancement of vitamin e activity in rats fed a low alpha-tocopherol diet. Lipids. 30(11):1019–28
    • Protects skin from UV damage Césarini JP, Michel L, Maurette JM, et al. 2003. Immediate effects of UV radiation on the skin: modification by an antioxidant complex containing carotenoids. Photodermatol. Photoimmunol. Photomed. 19(4):182–89 Lee J, Jiang S, Levine N, et al. 2000. Carotenoid supplementation reduces erythema in human skin after simulated solar radiation exposure. Proc. Soc. Exp. Biol. Med. 223(2):170–74 Gollnick HPM, Hopfenmüller W, Hemmes C, et al. 1996. Systemic beta-carotene plus topical UV-sunscreen are an optimal protection against harmful effects of natural UV-sunlight: results of the berlin-eilath study. European journal of dermatology. 6(3)(200-205) Stahl W, Heinrich U, Jungmann H, et al. 2000. Carotenoids and carotenoids plus vitamin E protect against ultraviolet light–induced erythema in humans. Am. J. Clin. Nutr. 71(3):795–98 Yamada Y, Obayashi M, Ishikawa T, et al. 2008. Dietary tocotrienol reduces uvb-induced skin damage and sesamin enhances tocotrienol effects in hairless mice. J. Nutr. Sci. Vitaminol. 54(2):117–23 Shibata A, Nakagawa K, Kawakami Y, et al. 2010. Suppression of gamma-tocotrienol on UVB induced inflammation in hacat keratinocytes and hr-1 hairless mice via inflammatory mediators multiple signaling. J. Agric. Food Chem. 58(11):7013–20 Traber MG, Podda M, Weber C, et al. 1997. Diet-derived and topically applied tocotrienols accumulate in skin and protect the tissue against ultraviolet light-induced oxidative stress. Asia Pac. J. Clin. Nutr. 6(1):63–67 Meinke MC, Friedrich A, Tscherch K, et al. 2012. Influence of dietary carotenoids on radical scavenging capacity of the skin and skin lipids. Eur. J. Pharm. Biopharm. 84(2):365–73 Stahl W, Sies H. 2012. β-carotene and other carotenoids in protection from sunlight. Am. J. Clin. Nutr. 96(5):1179S – 84S Chen L, Hu JY, Wang SQ. 2012. The role of antioxidants in photoprotection: a critical review. J. Am. Acad. Dermatol. 67(5):1013–24
    • References Regenerates youthful skin ‡ The claims related to improved skin appearance are substantiated with a study that used 40 mg tocotrienols and 2 mg astaxanthin per day. Palm Fruit™ contains at least 52 mg tocotrienols per serving, and although Palm Fruit™ does not contain astaxanthin, it contains 30 mg of carotenoids with similar structure and function as astaxanthin, and thus may provide comparable effects. Yamashita E. 2002. Cosmetic benefit of dietary supplements including astaxanthin and tocotrienol on skin. FOOD Style. 21(6(6)):112–17 Chin S-F, Hamid NAA, Latiff AA, et al. 2007. Reduction of DNA damage in older healthy adults by Tri E tocotrienol supplementation. Nutrition. 24(1):1–10 Astley SB, Elliott RM, Archer DB, et al. 2004. Evidence that dietary supplementation with carotenoids and carotenoid-rich foods modulates the DNA damage: repair balance in human lymphocytes. Br. J. Nutr. 91(1):63–72 Torbergsen AC, Collins AR. 2000. Recovery of human lymphocytes from oxidative DNA damage; the apparent enhancement of dna repair by carotenoids is probably simply an antioxidant effect. Eur. J. Nutr. 39(2):80–85 Makpol S, Azura Jam F, Anum Mohd Yusof Y, et al. 2011. Modulation of collagen synthesis and its gene expression in human skin fibroblasts by tocotrienol-rich fraction. Arch. Med. Sci. 7(5):889–95 Makpol S, Jam FA, Khor SC, et al. 2013. Comparative effects of biodynes, tocotrienol-rich fraction, and tocopherol in enhancing collagen synthesis and inhibiting collagen degradation in stress-induced premature senescence model of human diploid fibroblasts. Oxid. Med. Cell. Longev. 2013:298574 Patel V, Rink C, Gordillo GM, et al. 2012. Oral tocotrienols are transported to human tissues and delay the progression of the model for end-stage liver disease score in patients. J. Nutr. 142(3):513–19 Stahl W, Heinrich U, Jungmann H, et al. 1998. Increased dermal carotenoid levels assessed by noninvasive reflection spectrophotometry correlate with serum levels in women ingesting betatene. J. Nutr. 128(5):903–7 Blume-Peytavi U, Rolland A, Darvin ME, et al. 2009. Cutaneous lycopene and beta-carotene levels measured by resonance raman spectroscopy: high reliability and sensitivity to oral lactolycopene deprivation and supplementation. Eur. J. Pharm. Biopharm. 73(1):187–94
    • References Reverses age related hair loss Ho DSS, Yuen KH, Wong JW, et al. 2007. Palm fruit extract for hair growth: a human clinical trial. US Patent 7211274 B2 Beoy LA, Woei WJ, Hay YK. 2010. Effects of tocotrienol supplementation on hair growth in humans. Tropical Life Sciences Research. 21(2):91–99 Choi J-S, Jeon M-H, Moon W-S, et al. 2014. In vivo hair growth-promoting effect of rice bran extract prepared by supercritical carbon dioxide fluid. Biol. Pharm. Bull. 37(1):44–53 Panchaprateep R, Asawanonda P. 2014. Insulin-like growth factor-1: roles in androgenetic alopecia. Exp. Dermatol. Li W, Man X-Y, Li C-M, et al. 2012. VEGF induces proliferation of human hair follicle dermal papilla cells through VEGFR-2-mediated activation of ERK. Exp. Cell Res. 318(14):1633–40 Jang J-H. 2005. Stimulation of human hair growth by the recombinant human keratinocyte growth factor-2 (KGF-2). Biotechnol. Lett. 27(11):749–52 Rinaldi F, Bezzola P, Sorbellini E. 2003. The “substrate to energy” the importance of the diet and nutritional supplements in metabolic process of the hair bulb before and after transplant. EUROPEAN SOCIETY OF HAIR RESTORATION SURGERY. 3(2)

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