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  • Dermacrine

    The Worlds Most Powerful DHEA Gel

    Unlock your potential


    Dermacrine delivers a powerful blend of science-backed ingredients through our advanced topical gel. Each application provides a balance of bioidentical DHEA and Pregnenolone to support hormone optimization, 7,8-Benzoflavone to promote estrogen metabolism, and Resveratrol for antioxidant and cellular health benefits. Designed for men seeking enhanced energy, mood, recovery, and performance. Fast-absorbing, clean, and convenient—Dermacrine is your daily edge for staying sharp, lean, and balanced. Elevate your routine with this cutting-edge topical formula trusted by high-performers and wellness pros alike.

    $49.99
    $59.99

    Jesse F. Verified Buyer

    2 weeks so far and feeling great! Definitely feeling amazing mood wise and muscle fullness is strong!

    Why Dermacrine

    Optimize Hormone Levels

    boost Energy & Vitality

    Enhance Recovery & Performance

    Support Estrogen balance

    Antioxidant Protection

    Anti-aging

    Advanced delivery system

    • Application

    • Ingredients

    For best results, 3-5 pumps each morning.

     

    Best application sites are: chest, shoulders, upper arm, clavicle region, upper back

    Water, ethyl alcohol (organic), dimethyl isosorbide, ethoxydiglycol, propylene glycol monolaurate, Dehydroepiandrosterone (DHEA), Trans-resveratrol (98%), 7,8,benzoflavone (98%), tiethanolamine, carbomer, pregnenelone, tetrahydropiperine

    Most advanced DHEA product available on the market

    Delivers bioidentical DHEA and Pregnenolone to support testosterone, mood, and cognitive function.

    Supports Estrogen Balance

    7,8-Benzoflavone helps modulate estrogen for a leaner, harder physique

    Boost Energy & Vitality

    Naturally promotes stamina, motivation, and overall well-being

    Antioxidant Protection

    Resveratrol promotes cellular health and fights oxidative stress.

    Enhanced delivery

    Advanced gel delivery 

    Dries Fast

    Eeasy application and dries quickly!

    What is Dermacrine?  Dermacrine is a powerful topical hormone support gel featuring DHEA, Pregnenolone, 7,8-Benzoflavone, and Resveratrol—delivered through our industry-leading topical gel system. Designed for men seeking enhanced energy, hormonal balance, and physical performance, Dermacrine supports testosterone production, combats estrogen dominance, and promotes vitality—all without pills or injections.

     

    How Does Dermacrine Work? Dermacrine works by supplying your body with key hormonal precursors—DHEA and Pregnenolone—via a fast-absorbing gel. These compounds naturally support testosterone and other androgens, helping to improve mood, motivation, strength, and recovery. 7,8-Benzoflavone helps optimize estrogen metabolism, while Resveratrol offers antioxidant protection. The result? Better performance, better body composition, and better daily energy.

     

    Why Choose Dermacrine?

    • Total Hormone Optimization: Supports testosterone and other vital hormones with bioavailable DHEA and Pregnenolone.
    • Boosts Energy & Mood: Feel sharper, more focused, and motivated throughout the day.
    • Lean Muscle Support: Promotes lean gains and muscle retention, especially during cutting or PCT.
    • Estrogen Management: 7,8-Benzoflavone aids in keeping estrogen in check for a harder, leaner look.
    • Antioxidant Protection: Resveratrol helps combat oxidative stress and supports cellular health.
    • Superior Absorption: Advanced topical gel delivery bypasses digestion and liver breakdown for maximum effect.
    • All Day Support: Our topical gel slowly releases throughout the day so you don't have to continue taking pills throughout the day

    Who is Dermacrine For? Dermacrine is ideal for men looking to optimize hormones naturally—whether you’re cutting, or simply want to enhance energy, libido, and performance. It’s perfect for bodybuilders, athletes, and health-conscious men who want an effective, well-rounded hormonal edge without synthetic hormones or harsh side effects.

    Why Choose Dermacrine Over Oral Options?  Most oral hormone precursors get degraded in the gut or liver before doing their job. Dermacrine’s topical delivery system skips the digestive tract entirely, delivering key compounds directly into the bloodstream for faster, more efficient results. More bioavailability. Less waste. Superior impact.

     

    Suggested Use: Apply 2–4 pumps daily to clean, dry skin—preferably in the morning. Rotate application sites. Use for up to 12 weeks, followed by a 4-week break if cycling.

     

    Reclaim Your Edge—Naturally. Dermacrine is the smart, science-backed way to support your hormones, boost your energy, and perform at your best—every day.

    What is Dermacrine?  Dermacrine is a powerful topical hormone support gel featuring DHEA, Pregnenolone, 7,8-Benzoflavone, and Resveratrol—delivered through our industry-leading topical gel system. Designed for men seeking enhanced energy, hormonal balance, and physical performance, Dermacrine supports testosterone production, combats estrogen dominance, and promotes vitality—all without pills or injections.

     

    How Does Dermacrine Work? Dermacrine works by supplying your body with key hormonal precursors—DHEA and Pregnenolone—via a fast-absorbing gel. These compounds naturally support testosterone and other androgens, helping to improve mood, motivation, strength, and recovery. 7,8-Benzoflavone helps optimize estrogen metabolism, while Resveratrol offers antioxidant protection. The result? Better performance, better body composition, and better daily energy.

     

    Why Choose Dermacrine?

    • Total Hormone Optimization: Supports testosterone and other vital hormones with bioavailable DHEA and Pregnenolone.
    • Boosts Energy & Mood: Feel sharper, more focused, and motivated throughout the day.
    • Lean Muscle Support: Promotes lean gains and muscle retention, especially during cutting or PCT.
    • Estrogen Management: 7,8-Benzoflavone aids in keeping estrogen in check for a harder, leaner look.
    • Antioxidant Protection: Resveratrol helps combat oxidative stress and supports cellular health.
    • Superior Absorption: Advanced topical gel delivery bypasses digestion and liver breakdown for maximum effect.
    • All Day Support: Our topical gel slowly releases throughout the day so you don't have to continue taking pills throughout the day

    Who is Dermacrine For? Dermacrine is ideal for men looking to optimize hormones naturally—whether you’re cutting, or simply want to enhance energy, libido, and performance. It’s perfect for bodybuilders, athletes, and health-conscious men who want an effective, well-rounded hormonal edge without synthetic hormones or harsh side effects.

    Why Choose Dermacrine Over Oral Options?  Most oral hormone precursors get degraded in the gut or liver before doing their job. Dermacrine’s topical delivery system skips the digestive tract entirely, delivering key compounds directly into the bloodstream for faster, more efficient results. More bioavailability. Less waste. Superior impact.

     

    Suggested Use: Apply 2–4 pumps daily to clean, dry skin—preferably in the morning. Rotate application sites. Use for up to 12 weeks, followed by a 4-week break if cycling.

     

    Reclaim Your Edge—Naturally. Dermacrine is the smart, science-backed way to support your hormones, boost your energy, and perform at your best—every day.

    COMPARING TO THE COMPETITION

    Dermacrine

    Multiple Ingredient Formula

    Advanced Delivery & Increased Bioavailability 

    Convenient Application - Once Per Day

    Stable Hormone Levels

    Fewer Side Effects

    Other DHEA Supplements

    No - requires taking multiple pills 

    Low Oral Bioavailability 

    Must Take Multiple Pills Per Day

    No - large peaks and valleys in hormone levels throughout the day

    Higher sides with more conversion to undesired metabolites

    Frequently Asked Questions

    What is Dermacrine, and how does it work?

    Dermacrine is an advanced topical skin gel that delivers DHEA, Pregnenolone, 7,8-Benzoflavone, and Resveratrol to support hormone balance, boost energy, enhance mood, and promote lean muscle. It’s designed for men seeking natural testosterone support and improved physical and mental performance.

    Do I need to cycle off or use PCT for Dermacrine?

    Dermacrine doesn't introduce any extrernal androgenic properties and works with your body natural hormone levels, so it's not generally suppressive and does not require a PCT.  users may benefit from taking Sustain Alpha after use to boost natural testosterone levels 

    What are the best application sites for Dermacrine?

    For optimal delivery, we recommend applying to areas with thinner skin and lower subcutaneous bodyfat.  Ideal application sites include chest, shoulders, upper arms, upper back, clavicle region and neck

    What is the best time to apply Dermacrine?

    We always recommend applying in the morning.  for best results apply after a morning shower, after drying well.  wait 5 minutes before dressing

    Can I stack Dermacrine?

    Absolutely!  Dermacrine can be stacked with other supplements to enhance effects, build more muscle and increase performance

    Do I need to take liver support or cycle support?

    Dermacrine is not liver toxic and does not require liver support or cycle support

    Is Dermacrine safe for women?

    We do not recommend Dermacrine for women.

    What should I expect From Dermacrine

    With consistent use, expect increased energy, sharper focus, improved mood, and enhanced recovery. Dermacrine may support lean muscle maintenance, better workouts, and balanced hormones—especially during cutting phases, PCT, or times of low motivation. Results build gradually over several weeks.

    I'm On TRT, should I consider Dermacrine

    Yes—Dermacrine can complement TRT by supporting DHEA and Pregnenolone levels, which often drop during therapy. It may enhance mood, cognition, and well-being, especially if you're experiencing low energy or brain fog despite optimal testosterone levels. Always consult your doctor first.